Stochastic Mechanisms of Cell Fate Specification that Yield Random or Robust Outcomes
نویسندگان
چکیده
منابع مشابه
Stochastic mechanisms of cell fate specification that yield random or robust outcomes.
Although cell fate specification is tightly controlled to yield highly reproducible results and avoid extreme variation, developmental programs often incorporate stochastic mechanisms to diversify cell types. Stochastic specification phenomena are observed in a wide range of species and an assorted set of developmental contexts. In bacteria, stochastic mechanisms are utilized to generate transi...
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There are two sexes in C. elegans, hermaphrodite and male. While there are many sex-specific differences between males and hermaphrodites that affect most tissues, the basic body plan and many of its structures are identical. However, most structures required for mating or reproduction are sexually dimorphic and are generated by sex-specific cell lineages. Thus to understand cell fate specifica...
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BACKGROUND In culture, isogenic mammalian cells typically display enduring phenotypic heterogeneity that arises from fluctuations of gene expression and other intracellular processes. This diversity is not just simple noise but has biological relevance by generating plasticity. Noise driven plasticity was suggested to be a stem cell-specific feature. RESULTS Here we show that the phenotypes o...
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ژورنال
عنوان ژورنال: Annual Review of Cell and Developmental Biology
سال: 2010
ISSN: 1081-0706,1530-8995
DOI: 10.1146/annurev-cellbio-100109-104113